University Professor, Vice Head of Department
President of studies legislations and affairs University of Vienna
Department of Pharmacognosy
University of Vienna
Althanstr. 14
A-1090 Vienna, Austria
Research
Development of methods for quality assurance of herbal medicine products, phytopharmaceuticals and food supplements
Isolation and structure elucidation of natural compounds with immunregulatory, spasmolytic, choleretic or antiinflammatory activities
Analysis of natural compounds in biological matrices
Plant biotechnology for the production of high quality medicinal plants and natural products
In vitro propagation of endangered medicinal plants
Patents
Kern E, Kopp B, Locker G, Schmiedinger M, Zielinski Ch. Pflanzliche Zusammensetzung zur Behandlung von erythematösen Hautveränderungen,
Europäische Patentanmeldung Nr. 05005868 4- vom 10.05.2005
Terness P, Kopp B, Navolan D. Use of Bufadienolide Derivatives as Immunsuppressive and Anti-Inflammatory Drugs, Europäisches Patent Nr. 00 117 675.9 vom 28.08.2000
Kopp B, Wawrosch C. EU-Sortenschutz Nr. EU5559 vom 6. 12. 1999 für Tussilago farfara L. cv. 'Wien' (end: 31. 12. 2024)
Publications in peer reviewed journals
Singhuber J, Khom S, Zehl M, Urban E, Hering S, Kopp B. GABAA receptor modulators from the Chinese herbal drug Junci Medulla, the pith of Juncus effusus L., Planta medica, 2012.
Sellinger M, Popescu R, Seephonkai P, Singhuber J, Giessrigl B, Unger Ch, Bauer S, Wagner K, Fritzer-Szekeres M, Szekeres T, Tut F, Frisch R, Feistel B, Kopp B, Krupitza G, Diaz R. Fractionation of an extract of Pluchea odorata separates a property indicative for the induction of cell plasticity from one that inhibits a neoplastic phenotype, Evidence-Based Complementary and Alternative Medicine, in print 2012.
Novak J, Wawrosch C, Schmiderer C, Franz C, Kopp B. Germination responses of Peucedanum ostruthium (Apiaceae) to Genotype, Light, Temperature and Gibberellic Acid, Seed Science and Technology, 39: 552-558, 2011.
Singhuber J, Baburin I, Kählig H, Urban E, Kopp B, Hering S. GABAA receptor modulators from Chinese Herbal Medicines traditionally applied against insomnia and anxiety, Phytomedicine, 2011, doi: 10.1016/j.phymed.2011.10.009.
Weinoehrl S, Feistel B, Pischel I, Kopp B, Butterweck V. Comparative evaluation of two different Artemisia dracunculus L. cultivars for blood sugar lowering effects in rats, Phytotherapy Research, 2011, doi: 10.1002/ptr.3605.
Kizaibek M, Popescu R, Prinz S, Upur H, Singhuber S, Zehl M, Kopp B. Towards modernization of the formulation of the Traditional Uighur Medicine herbal preparation Abnormal Savda Munziq, Evidence-Based Complementary and Alternative Medicine (ECAM), vol. 2012, Article ID 863101, 10 pages, 2012.doi:10.1155/2012/863101.
Singhuber S, Baburin I, Ecker G, Kopp B, Hering S. Insights into structural requirements of GABA A receptor modulating coumarins and furanocoumarins, European Journal of Pharmacology, 668: 57 — 64, 2011.
Joa H, Vogl S, Atanasov A, Zehl M, Nakel T, Fakhrudin N, Heiss E, Picker P, Urban E, Wawrosch C, Saukel J, Reznicek G, Kopp B, Dirsch V. Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation, J.Nat.Product 74(6): 1513-1516, 2011.
Gründemann C, Gruber C, Hertrampf A, Zehl M, Kopp B, Huber R. An Aqueous birch leaf extract of Betula pendula inhibits the growth and cell division of inflammatory lymphocytes, J ournal of Ethnopharmacology 136: 444-451, 2011.
Seephonkai P, Popescu R, Zehl M, Krupitza G, Urban E,
Kopp B. Ferruginenes A-C from Rhododendron ferrugineum and Their Cytotoxic Evaluation. J Nat Prod 74(4): 712-717, 2011.
Vogl S, Zehl M, Picker P, Urban E, Wawrosch C, Reznicek G, Saukel J, Kopp B. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS. J. Agricultural and Food Chemistry 59(9): 4371-4377, 2011.
Popescu R, Heiss EH, Ferk F, Peschel A, Knasmueller S, Dirsch VM, Krupitza G, Kopp B. Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells. Mutat Res-Fund Mol M 709 — 710: 60 — 66, 2011.
Gao H, Popescu R, Kopp B, Wang Z. Bufadienolides and their antitumor activity. Nat Prod Rep 28: 953 — 969, 2011.
Bauer S, Singhuber J, Seelinger M, Unger C, Viola K, Vonach C, Giessrigl B, Madlener S, Stark N, Wallnöfer B, Wagner K-H, Fritzer-Szekeres M, Szekeres T, Diaz R, Tut FM, Frisch R, Feistel B, Kopp B, Krupitza G, Popescu R. Separation of anti-neoplastic activities by fractionation of a Pluchea odorata extract. Front Biosci (Elite Ed.) 3: 1326 – 1336, 2011.
Gao H, Zehl M, Leitner A, Wu X, Wang Z, Kopp B. Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS, J Ethnopharmacol, 131: 368-76, 2010.
Gao H, Zehl M, Kaehlig H, Schneider P, Stuppner H, Moreno Y. Banuls L, Kiss R, Kopp B. Rapid Structural Identification of Cytotoxic Bufadienolide Sulfates in Toad Venom from Bufo melanosticus by LC-DAD-MS n and LC-SPE-NMR. J Nat Prod 73: 603-608, 2010.
Khan M, Giessrigl B, Vonach C, Madlener S, Prinz S,
Herbaceck I, Hölzl C, Bauer S, Viola K, Mikulits W,
Aleem Quereshi R, Knasmüller S, Grusch M, Kopp B,
Krupitza G. Berberine and a Berberis lycium extract inactivate Cdc25A and induce α-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mut Res 683: 123-130, 2010.
Gridling M, Popescu R, Kopp B, Wagner K-H, Krenn L, Krupitza G. Anti-leukaemic effects of two extract types of Lactuca sativa correlate with the activation of Chk2, induction of p21, downregulation of cyclin D1 and acetylation of α-tubulin. Oncology Reports, 23: 1145-51, 2010.
Prinz S, Schauberger D, Bauer I M, Knasmueller S, Kopp B. Aneugenic 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) in sprouts of Triticum aestivum cultivars – A ‘safety health food’?. Food Chemistry 121: 973-979, 2010.
Nell M, Wawrosch C, Steinkellner S, Vierheilig H, Kopp B, Lössl A, Franz C, Novak J, Zitterl-Eglseer K. Root Colonization by Symbiotic Arbuscular Mycorrhizal Fungi Increases Sesquiterpenic Acid Concentrations in Valeriana officinalis L. Planta Med 76: 393-398, 2010.
Luo JP, Wawrosch Ch, Kopp B. Enhanced micropropagation of Denrdobium huoshanense C.Z. Tang et S.J. Cheng through procotorm-like bodies: The effects of cytokinins, carbohydrate sources and cold pretreatment. Sci Hortic, 123: 258-262, 2009.
Wawrosch C, Benda E, Kopp B. An Improved 2-step Liquid Culture System for Efficient In Vitro Shoot Proliferation of Sundew ( Drosera rotundifolia L.). Sci Pharm 77: 827-835, 2009.
Singhuber J, Zhu M, Prinz S, Kopp B. Aconitum in Traditional Chinese Medicine — a valuable drug or an unpredictable risk? J Ethnopharmacol 126(1): 18-30, 2009.
Stark N, Gridling M, Madlener S, Bauer S, Lackner A, Popescu R, Diaz R, Tut FM, Vo TPN, Vonac C, Giessrigl B, Saiko P, Grusch M, Fritzer-Szekeres M, Szekeres T, Kopp B, Frisch R, Krupitza G. A polar extract of the Maya healing plant Anthurium schlechtendalii (Aracea) exhibits strong in vitro anticancer activity. Int J Mol Med 24: 513-521, 2009.
Montri N, Wawrosch C, Kopp B. In vitro propagation of Stemona Tuberosa Lour., an antitussive medicinal herb. Acta Hort. 812: 165-172, 2009.
Schmid D, Gruber M, Woehs F, Prinz S, Etzlstorfer B, Prucker C, Fuzzati N, Kopp B, Moeslinger T. Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa ( Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages. J. Pharm. Pharmacol. 61(8), 1089-1096, 2009.
Schmid D, Gruber M, Woehs F, Prinz S, Etzlstorfer B, Prucker C, Fuzzati N, Kopp B, Moeslinger T. Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa ( Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages. J Pharm Pharmacol, 61: 1089–1096,2009.
Gridling M, Stark N, Madlener S, Lackner A, Popescu R, Benedek B, Diaz R, Tut FM, Nha Vo TP, Huber D, Gollinger M, Saiko P, Ozmen A, Mosgoeller W, De Martin R, Eytner R, Wagner KH, Grusch M, Fritzer-Szekeres M, Szekeres T, Kopp B, Frisch R, Krupitza G. In vitro anti-cancer activity of two ethno-pharmacological healing platns from Guatemala Pluchea odorata and Phlebodium decumanum. Int J Oncol 34(4): 1117-28, 2009.
Maier-Salamon A, Trauner G, Hiltscher R, Reznicek G, Kopp B, Thalhammer T, Jäger W. Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: Role of Mrp2 (Abcc2). J Pharm Sci´ 98(10): 3839-3849 2009.
Neuhaus W, Trauner G, Gruber D, Oelzant S, Klepal W, Kopp B, Noe CR. Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L . s. l. across an inVitro cell culture model of the blood-brain barrier. Planta Med 74 (11): 1338-1344, 2008.
Schlangen K, Halbwirth H, Peterek S, Gosch C, Ringl A, Fischer TC, Treutter D, Forkmann G, Kopp B, Stick K. Transient induction of antimicrobial 3-deoxyflavonoids does not affect pharmacological compounds in hawthorn. Nat Prod Commun, 3 (8): 1245-1250, 2008.
Bader Y, Madlener S, Strasser S, Maier S, Saiko P, Stark N, Popescu R, Huber D, Gollinger M, Erker T, Handler N, Szakmary A, Jäger W, Kopp B, Tentes I, Fritzer- Szekeres M, Krupitza G, Szekeress T. Stilbene analogues affect cell cycle progression and adoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds. Oncology Reports 19: 801-810, 2008.
Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B. Modulation of GABAA Receptors by Valerian Extracts is related to the Content of Valerenic Acid. Planta Med 74: 19-24, 2008.
Prinz S, Ringl A, Huefner A, Pemp E, Kopp B. 4´´´-Acetylvitexin-2´´-O- rhamnoside, Isoorientin Orientin and 8-Methoxykaempferol-3-O-glucoside as Markers for the Differentiation of Crataegus monogyna and Crataegus pentagyna from Crataegus laevigata (Rosaceae). Chem. Biodiv. 4: 2920-2931, 2007.
Benedek B, Kopp B, Melzig MF. Achillea millefolium L. s.l.- is the antiinflammatory activity mediated by protease inhibition? Journal of Ethnopharmacology 113: 312-317, 2007.
Benedek B, Rothwangl-Wiltschnigg K, Rozema E, Gjoncaj N, Reznicek G, Jurenitsch J, Kopp B, Glasl S. Yarrow ( Achillea millefolium L. s. l.): Pharmaceutical Quality of Commercial Samples. Pharmazie 63: 23-26, 2008.
Kern E, Schmidinger M, Locker GJ, Kopp B. Management des Capecitabin induzierten Hand-Fuß Syndroms durch lokale Phytotherapie. Wiener Medizinische Wochenschrift 157/13-14: 337-342, 2007.
Benedek B, Kopp B. Achillea millefolium L. s.l. revisited: Recent findings confirm the traditional use. Wiener Medizinische Wochenschrift 157/13-14: 312-314, 2007.
Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S. Valerenic Acid Potentiates and Inhibits GABAA Receptors: Molecular Mechanism and Subunit Specificity. Neuropharmacology 53: 178-187, 2007.
Benedek B, Gjoncaj N, Saukel J, Kopp B. Distribution of Phenolic Compounds in Middleeuropean Taxa of the Achillea millefolium L. Aggregate. Chem Biodiv 4: 849-857, 2007.
Ringl A, Prinz S, Huefner A, Kurzmann M, Kopp B. Chemosystematic Value of Flavonoids from Crataegus x macrocarpa (Rosaceae) with special Emphasis on ®— and (S)-Eriodictyol-7-O-glucuronide and Luteolin-7-O- glucuronide. Chem Biodiv 4: 154-162, 2007.
Buchmann CA, Nersesyan A, Kopp B, Schauberger D, Darroudi F, Grummt T, Krupitza G, Kundi M, Schulte-Hermann R, Knasmüller S. 2,4-Dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA), two naturally occurring benzoxazinones contained in sprouts of Gramineae are potent aneugens in human derived liver cells (HepG2). Cancer Letters 246: 290-299, 2007.
Vendl O, Wawrosch Ch, Noe C, Molina C, Kahl G, Kopp B. Diosgenin contents and DNA fingerprint screening of various Yam (Dioscorea sp.) genotypes. Z Naturforsch 61c: 847-855, 2006.
Singh BM, Wawrosch C, Joshi SD, Kopp B. Micropropagation of Butea buteiformis (Voigt) Grierson and Long. Nepal Journal of Science and Technology 7: 119-122, 2006.
Montri N, Wawrosch Ch, Kopp B. Micropropagation of Stemona curtisii Hook f., a Thai Medicinal Plant. Acta Hort 725: 341-346, 2006.
Benedek B, Geisz N, Jäger W, Thalhammer T, Kopp B. Choleretic effects of yarrow (Achillea millefolium s.l.) in the isolated perfused rat liver. Phytomedicine 13: 702-706, 2006.
Lemmens-Gruber R, Marchart E, Rawnduzi P, Engel N, Benedek B, Kopp B. Investigation of the spasmolytic activity of the flavonoid fraction of Achillea millefolium s.l. on isolated guinea-pig ilea. Arzneimittelforschung/Drug Research 56: 582-588, 2006.
Wawrosch C, Hugh-Bloch A, Hostettmann K, Kopp B. Swertia chirata Buch.-Ham. ex Wall. (Gentianaceae), an endangered Himalayan medicinal plant: comparative study of the secondary compound patterns in market drug, in vitro-cultivated, and micropropagated field grown samples. Sci Pharm 73: 127-137, 2005.
Pietsch J, Oertel R, Trautmann S, Schulz K, Kopp B, Dreßler J. A non-fatal oleander poisoning. Int J Legal Medicine 119(4): 236-240 (2005).
Wawrosch C, Kongbangkerd A, Köpf A, Kopp B. Shoot regeneration from nodules of Charybdis sp.: a comparison of semisolid, liquid and temporary immersion culture systems. Plant Cell Tissue Organ Cult 81: 319-322, 2005.
Kongbangkerd A, Köpf A, Allacher P, Wawrosch C, Kopp B. Micropropagation of squill (Charybdis numidica) through nodule culture. Plant Cell Reports 23: 673-677, 2005.
Book chapters and other publications
Kopp B. Phytotherapie bei Atemwegserkrankungen. Ärztemagazin 49: 20-23, 2009.
Prinz S, Kopp B. Hoodia gordonii — der neue Appetitzügler? Österreichische Apothekerzeitung 60 (6): 288-289, 2006.
Wawrosch C, Kongbangkerd A, Köpf A, Kopp B. Shoot regeneration from nodules of Charybdis sp.: a comparison of semisolid, liquid and temporary immersion culture systems, in: Liquid Culture Systems for in vitro Plant Propagation, Hvoslef-Eide AK, Preil W (Eds.), pp. 275-280, Springer 2005.
Prinz S, Kopp B. Paffia paniculata – die Suma-Wurzel, Österreichische Apothekerzeitung 59 (14): 668-669, 2005
Prinz S, Kopp B. Momordica charantia — Die hypoglykämische Wirkung der Bittermelone bei Typ II-Diabetes. Österreichische Apothekerzeitung 58 (3): 111-113, 2004.
Prinz S, Kopp B. Papaya — Immunmodulierend bei HIV-Patienten? Österreichische Apothekerzeitung 58 (9): 410-412, 2004.
Kopp B. Vitex Agnus Castus aus pharmakognostischer Sicht, Gyn-Aktiv 02, 60-61, 2003.
Further activities
Member of the expert committee 13B (phytochemistry) of the European Pharmacopoea, Strasbourg
President of the Society for Medicinal Plant Research
(GA, Gesellschaft für Arzneipflanzenforschung)Member of the Board of Directors of the Austrian Society of Phytotherapy
(Österreichische Gesellschaft für Phytotherapie)Austrian Representative since 1994 of the EC Committee on Pharmaceutical Education and Training, Brussel.
Austrian Representative since 1993 of the European Association of Faculties and Schools of Pharmacy
Coordinator for ERASMUS/SOCRATES-Program
Austrian National Rapportieur for the IMS European Price for Research in Pharmaceutical Law and Health Economics
Member of the Editorial Board of Scientia Pharmaceutica, Foliaca
Member of the expert group of the FAH (Forschungsvereinigung der Arzneimittel-Hersteller, BRD)
Member of several scientific societies, referee for several journals, member of the scientific committee of congresses.
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